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All Orthopaedics. J Am Soc Nephrol , Nat Genet , Pediatr Nephrol , Therefore, following volume expansion, the peritubular capillary protein concentration falls, while the hydrostatic pressure rises, both of which reduce proximal tubular sodium reabsorption.
With volume contraction, however, peritubular capillary protein concentration rises and peritubular capillary hydrostatic pressure falls, both of which increase tubular sodium reabsorption. Sall1 Sall1, a transcription factor, is expressed in the metanephric mesenchyme at the time of induction by the ureteric bud. In Sall1-deficient mice, ureteric bud outgrowth occurs, but the bud fails to invade the metanephric blastema, resulting in renal agenesis.
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